P-215: Combination of Antioxidant and Ovulation Induction Drugs and Evaluation of Pregnancy Rate in Infertile Women

Background: Many studies reported that antioxidants such as vitamin E, vitamin C help to scavenge the oxygen radicals throughout the female reproductive tract that might improve the infertility treatment. The aim of this research is to adjust a regimen that is a combination of antioxidant and ovulation induction drugs and evaluation of pregnancy rate. Materials and Methods: This is a clinical study which was done on 202 infertile women who referred to Dr.Rasekh clinic in Jahrom city during 24 months.Results are reported as number and percentage and the Chi-square test.All these patients were treated with regimen including letrozole+ tamoxifen +estrogen + vitamin E.Most of the women in this study were in range of 20-30 years old(63.4%). 24.8% of patients were case of PCO syndrome. Frequency of pregnancy was reported based on endometrial quality, endometrial thickness and follicular size. Data was analyzed by SPSS 21. Results: At the end of the study 25.7% of patients who were treated with this regimen was pregnant. 44.6% of follicular sizes were more than 18 mm. 68.7% of patients had high quality of endometrium (triple layer and lucid). 71.6% of endometrial thickness was more than 8 mm. Conclusion: Based on the results of this study, this regimen can improve the endometrial quality and thickness which are required for successful implantation of fetus in uterus. Also this regimen had acceptable effects on follicular size which is one of the basic steps in success of ovulation induction. Pregnancy occurred in 1 woman among 4 infertile women. For evaluation of the results, this study must be done on numerous infertile patients to achieve meaningful results. Other important factor are availability of drugs and low cost.